J. Pediatr. Gastroenterol. Nutr.: 健康且哺乳嬰兒的腸道微生物與免疫標記物在副食哺餵期間之轉變

Amarri et al. (2006) Changes of Gut Microbiota and Immune Markers During the Complementary Feeding Period in Healthy Breast-fed Infants. Journal of Pediatric Gastroenterology and Nutrition.

1. 簡介

嬰兒無菌的腸道在出生後逐漸被細菌拓殖。雖然各研究的結果有些差異，但親餵與瓶餵的嬰兒之腸道微生物發育模式不同，哺乳嬰兒的腸道往往有較多的 bifidobacteria 和較少的 Enterobacteriaceae。在副食添加期間，哺乳的嬰兒腸道中的 enterobacteria 和 enterococci 數量漸增，隨後 Bacteroides、clostridia 和厭氧性 streptococci 也逐漸拓殖。

在離乳之後，親餵與瓶餵的嬰兒腸道的厭氧微生物逐漸演變為似於成年人腸道菌群的組成，同時兼性厭氧菌的數量也逐漸下降。目前，探討嬰兒腸道微生物演替在添加副食品和離乳期間的研究有限，少數以此為題的研究之定群規模和追蹤時數也不足。

鑒於嬰兒腸道微生物對幼兒往後健康狀況的重要性，此研究的目的是探討數種腸道微生物，以及免疫標記和腸漏指標物在嬰兒添加副食期間的轉變。

2. 解析

此文的寫法是依序解釋嬰兒腸道微生物的演替、哺乳相關的微生物相差異、腸道微生物與免疫的關聯等主題的研究成果，然後說明相關主題沒人做，所以自己跳下來做。我覺得這種寫法比較不有趣，因為沒有講解為什麼別人不做，也沒有講解解決問題的推理過程，讓人感覺問題之所以被解決，是增加資源而不是有什麼新的觀點。

3. 句型

At present, the knowledge concerning changes of the predominant gut microbiota during the period of complementary feeding (introduction of food and drink other than breast milk) is limited to a few reports with a restricted number of children, different intervals of breast-feeding and relatively short follow-up periods.

In view of the importance of gaining more knowledge in this area, the primary objective of this descriptive study was to investigate changes of selected gut microbiota in exclusively breast-fed infants during the complementary feeding period (from ages 4 to 9 months) and to evaluate changes of markers of immune function and gut permeability (secondary objectives) during this important period of life.